ABSTRACT: Complete denture therapy is full-mouth rehabilitation without the benefit of supporting teeth for stability and esthetic guidance. Consequently, the clinician is faced with both functional and esthetic challenges when restoring the patient’s oral condition with this treatment modality. However, these challenges offer an opportunity for the dentist to offer the patient a cosmetic makeover. Through enhanced tooth selection and arrangement, it is possible to provide an improved esthetic outcome for the patient. The purpose of this article is to present guidelines for tooth selection and arrangement, and also to discuss a popular tangential topic of interest: postoperative maintenance for the complete denture patient.